๐”– Bobbio Scriptorium
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Nucleoside analogs with antiviral activity

โœ Scribed by William H. Prusoff; David C. Ward


Book ID
115772907
Publisher
Elsevier Science
Year
1976
Tongue
English
Weight
940 KB
Volume
25
Category
Article
ISSN
0006-2952

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Robust antiviral activity of R1626, a no
โœ Stuart K. Roberts; Graham Cooksley; Gregory J. Dore; Richard Robson; David Shaw; ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 511 KB

The nucleoside analog R1479 is a potent and highly selective inhibitor of nonstructural protein 5B-directed hepatitis C virus (HCV) replication in vitro. R1626, a tri-isobutyl ester prodrug of R1479, was developed to increase bioavailability and improve antiviral activity. A multicenter, observer-bl