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Synthesis and antiviral activity of enantiomeric forms of cyclobutyl nucleoside analogs

✍ Scribed by Bisacchi, Gregory S.; Braitman, Abbe; Cianci, Christopher W.; Clark, Junius M.; Field, A. Kirk; Hagen, Moira E.; Hockstein, Deborah R.; Malley, Mary F.; Mitt, Toomas


Book ID
118242456
Publisher
American Chemical Society
Year
1991
Tongue
English
Weight
981 KB
Volume
34
Category
Article
ISSN
0022-2623

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A synthetic approach to phosphonate derivatives of 2,5-cis-substituted dihydro-2H-pyranyl nucleosides has been developed and both series of enantiomers (3 and 4) have been prepared. The key step in the synthetic pathway was the introduction of the phospbonomethoxy moiety on pentopyranosyl glycals th