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Nucleophilic reactions of propargyl acetates mediated by titanocene dichloride and magnesium

โœ Scribed by Fanglong Yang; Gang Zhao; Yu Ding

Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
86 KB
Volume
42
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

Reaction of Cp 2 TiCl 2 /Mg with propargyl acetates form allenyl titanium intermediates, which undergo nucleophilic addition reactions to aldehydes or ketones to give homopropargyl alcohols in high yields. Subsequent nucleophilic addition to acetonitrile and nucleophilic substitution with allyl bromide are also mentioned.

๐Ÿ“œ SIMILAR VOLUMES

Indium mediated allylation and propargyl
Indium mediated allylation and propargylation reactions of dimethyl acetals and ketals
โœ Jin Sun Kwon; Ae Nim Pae; Kyung Il Choi; Hun Yeong Koh; Youseung Kim; Yong Seo C ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 115 KB

Indium mediated allylation and propargylation reactions of acetals and ketals with various allyl or propargyl bromides in aqueous media successfully provided the corresponding homoallylic or homopropargylic (and allenylic) alcohol, respectively, in moderate to good yields. Highly chemoselective ally