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Nucleophilic Carbenes in Synthesis. [1 + 4] Cycloaddition of Bis(alkylthio)carbenes with Vinyl Isocyanates

✍ Scribed by Rigby, James H.; Laurent, Stéphane


Book ID
127264808
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
125 KB
Volume
64
Category
Article
ISSN
0022-3263

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Asymmetric induction in [1+4] cycloaddit
✍ James H. Rigby; Alexandre Cavezza; Mary Jane Heeg 📂 Article 📅 1999 🏛 Elsevier Science 🌐 French ⚖ 214 KB

Several chirally-modified nucleophilic carbenes afford useful levels of asymmetric induction during [1+4] cycloaddition with vinyl isocyanate reaction partners. Carbenes derived from the 1,2-aminoalcohols (1R,2S)-ephedrine and (1R,2S)-methylaminoindanol proved to be the most effective for delivering