Nucleophilic aromatic substitution of methyl 3-nitropyridine-4-carboxylate

✍ Scribed by Jarle Holt; Freddy Tjosås; Jan M. Bakke; Anne Fiksdahl

• Publisher: Journal of Heterocyclic Chemistry
• Year: 2004
• Tongue: English
• Weight: 35 KB
• Volume: 41
• Category: Article
• ISSN: 0022-152X
• DOI: 10.1002/jhet.5570410622

✦ Synopsis

Abstract

The nitro group of methyl 3‐nitropyridine‐4‐carboxylate (1) has successfully been replaced by nitrogen, oxygen and sulphur nucleophiles by nucleophilic aromatic substitution to give the 3‐azido, 3‐methoxy, 3‐phenoxy and 3‐thiophenoxypyridine‐4‐carboxylates (2a — d).