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Nucleophilic Aromatic Substitution of Methacrylamide Anion and Its Application to the Synthesis of the Anticancer Drug Bicalutamide

✍ Scribed by Chen, Bang-Chi; Zhao, Rulin; Gove, Stacey; Wang, Bei; Sundeen, Joseph E.; Salvati, Mark E.; Barrish, Joel C.

Book ID: 115547976
Publisher: American Chemical Society
Year: 2003
Tongue: English
Weight: 38 KB
Volume: 68
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo035377c

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## Abstract A steric and electronic effect on enamide/ene metathesis, a novel preparation of 2‐substituted indoles and 3‐substituted indoles using enamide‐ene metathesis as a key reaction, and its application to the synthesis of indomethacin are described. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451