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Nucleophilic Additions to Nitrones: An Alternative Gateway to Isoxazolidines, Pyrrolidines and Related Compounds

✍ Scribed by Pedro Merino


Book ID
101978172
Publisher
John Wiley and Sons
Year
2005
Weight
8 KB
Volume
36
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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πŸ“œ SIMILAR VOLUMES


Pyrrolidine N-Oxides by Stereoselective
✍ AndreasΒ M. Palmer; Volker JΓ€ger πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 493 KB πŸ‘ 1 views

The addition of Grignard reagents to D-erythro-4-pentenose N-benzyl nitrone 5, which is easily accessible from D-ribose, furnishes Ο‰-unsaturated hydroxylamines that readily undergo Cope-House cyclization to afford pyrrolidine N-oxides. The stereoselectivity of the addition step is altered by either