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Nucleophilic Addition of Nitrones to Ketones: Development of a New Catalytic Asymmetric Nitrone-Aldol Reaction.

✍ Scribed by Anders Boegevig; Kurt V. Gothelf; Karl Anker Joergensen


Publisher
John Wiley and Sons
Year
2003
Weight
236 KB
Volume
34
Category
Article
ISSN
0931-7597

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✦ Synopsis


Abstract

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Nucleophilic Addition of Nitrones to Ket
✍ Anders BΓΈgevig; Kurt V. Gothelf; Karl Anker JΓΈrgensen πŸ“‚ Article πŸ“… 2002 πŸ› John Wiley and Sons 🌐 English βš– 210 KB πŸ‘ 2 views

A new organic reaction has been discovered in which nitrones react with carbonyl compounds in an aldoltype reaction to give functionalized beta-hydroxynitrones. The alpha-carbon atom of the nitrone undergoes a nucleophilic addition reaction to electron-deficient ketones, such as alpha-ketoesters, al