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ChemInform Abstract: A New Version of the Reverse-Cope Elimination Initiated by the Nucleophilic Addition of Allylamines to Nitrones: A Synthesis of Vicinal Diamines.

โœ Scribed by Michael B. Gravestock; David W. Knight; K. M. Abdul Malik; Steven R. Thornton


Publisher
John Wiley and Sons
Year
2010
Weight
40 KB
Volume
32
Category
Article
ISSN
0931-7597

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ChemInform Abstract: A New, Stereoselect
โœ A. R. WHEILDON; D. W. KNIGHT; M. P. LEESE ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons โš– 31 KB ๐Ÿ‘ 1 views

I) and addition of nitrones (II) results in a smooth condensation to give the unsaturated hydroxylamines (III) stereoselectively. These undergo reverse-Cope cyclizations at room temperature leading to the diastereomeric mixture of pyrrolidine-N-oxides (IV) and (V). -