Nucleophilic Acylation with β-Acyl Enamines

✍ Scribed by Prof. Dr. Richard R. Schmidt; Jörg Talbiersky

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 229 KB
• Volume: 15
• Category: Article
• ISSN: 0044-8249
• DOI: 10.1002/anie.197601711

✦ Synopsis

Our observations demonstrate that the Co-C bond of enzyme-bound ( I ) is not alternately closed and broken during the catalytic reaction with the substrate. If this were so, irradiation of the enzyme complex should not have had any significant effect on the rate of the subsequent enzymatic reaction in the dark.

The present results do not necessarily support the currently popular idea that coenzyme B, dependent enzymatic reactions occur cia organic radicals and that the coenzyme is activated enzymatically by the homolysis of the C 4 bond. On the contrary, our findings are fully consistent with the previously postulatedr7-heterolytic mechanism of enzymatic coenzyme B,,-activation"