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Nucleophilic activation of a nitrile group: Synthesis of trifluoromethyl substituted 4H-1,3,5-dioxazines

✍ Scribed by Kostiantyn V. Turcheniuk; Igor V. Shevchenko


Book ID
113711620
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
296 KB
Volume
135
Category
Article
ISSN
0022-1139

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A convenient synthesis of 4-trifluoromet
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## Abstract 1,1,1‐Trifluoroalkane‐2,3‐dione 3‐oximes 1 easily obtainable from aldehyde dimethylhydrazones were reacted with several aldehydes and ketones in the presence of acetic acid to afford 4‐trifluoromethyl‐4__H__‐[1,5,2]dioxadines 3 in satisfactory yields. When the reaction was carried out i