Nucleocytoplasmic Transport of MicroRNAs and Related Small RNAs
β Scribed by Jun Katahira; Yoshihiro Yoneda
- Book ID
- 111268544
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 834 KB
- Volume
- 12
- Category
- Article
- ISSN
- 1398-9219
No coin nor oath required. For personal study only.
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## Abstract Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and dru
Much is known about the mechanism by which mRNAs cross the nuclear envelope (the translocation stage of nucleocytoplasmic transport), but far less is known about the preceding (intranuclear migration/release) and succeeding (cytoplasmic binding) stages. Therefore, existing information suffices for a