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MicroRNAs and other small silencing RNAs in cancer

✍ Scribed by Carlos Rovira; Maria C. Güida; Alfonso Cayota

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
126 KB
Volume
62
Category
Article
ISSN
1521-6543

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✦ Synopsis

Abstract

Small noncoding RNAs are key controllers of cellular function, and their deregulation can lead to cancer development and metastatic evolution. This review summarizes the most important examples of small RNAs involved in human cancer and discusses their clinical use as biomarkers and drug targets for diagnosis, prognosis, and treatment of cancer. We also describe the possible mechanisms underlying small RNA‐mediated transformation and outline the future describing new small RNA families with great potential in cancer biology. © 2010 IUBMB IUBMB Life, 62(12): 859–968

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