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Nucleocapsid Protein Annealing of a Primer–Template Enhances (+)-Strand DNA Synthesis and Fidelity by HIV-1 Reverse Transcriptase

✍ Scribed by Jiae Kim; Anne Roberts; Hua Yuan; Yong Xiong; Karen S. Anderson


Book ID
116664752
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
1024 KB
Volume
415
Category
Article
ISSN
0022-2836

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The conformation of the DNA and the interactions of the nucleic acid with the protein in a complex of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) and a 19-mer/18-mer double-stranded DNA template-primer (dsDNA) are described. The structure of this HIV-1 RT complex with dsDN