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✦ LIBER ✦

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Nucleic Acids and Molecular Biology

✍ Scribed by E. Paleček (auth.), Prof. Dr. Fritz Eckstein, Prof. Dr. David M. J. Lilley (eds.)

Publisher: Springer-Verlag Berlin Heidelberg
Year: 1994
Tongue: English
Leaves: 340
Series: Nucleic Acids and Molecular Biology 8
Edition: 1
Category: Library

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✦ Synopsis

Molecular biology is one of the most rapidly developing and at the same time most exciting disciplines. The key to molecular biology lies in the understanding of nucleic acids - their structure, function, and interaction with proteins.
Nucleic Acids and Molecular Biology keeps scientists informed of the explosively growing information and complies with the great interest in this field by offering a continued high standard of review. A substantial part of this volume has been devoted to the analysis of different aspects of nucleic acid-protein-interactions including RNA-protein-interaction.

✦ Table of Contents

Front Matter....Pages I-XI
Probing of DNA Structure with Osmium Tetroxide Complexes in Vitro and in Cells....Pages 1-13
The Convertible Nucleoside Approach: Structural Engineering of Nucleic Acids by Disulfide Cross-Linking....Pages 14-40
Cryo-Electron Microscopy of DNA....Pages 41-55
The Hairpin Elements of Nucleic Acid Structure: DNA and RNA Folding....Pages 56-104
The Hairpin Ribozyme....Pages 105-118
Conformation and Energetics of Supercoiled DNA: Experimental and Theoretical Studies....Pages 119-132
Supercoiling Induced by Transcription....Pages 133-146
Topological Coupling between Promoters....Pages 147-166
Bleomycin-DNA Interactions....Pages 167-183
Adaptability and Specificity in DNA Binding by trp Repressor....Pages 184-196
The β Sliding Clamp of E. coli DNA Polymerase III Holoenzyme Balances Opposing Functions....Pages 197-216
Structure and Function of T4 Endonuclease V....Pages 217-226
Structure and Function of the DNA Repair Enzyme Endonuclease III....Pages 227-235
Resolvase-Mediated Site-Specific Recombination....Pages 236-267
Mechanism of Site-Specific Recombination: The Flp Paradigm....Pages 268-286
Achilles’ Cleavage: Conferring the Specificities of DNA-Binding Molecules on Restriction Endonucleases....Pages 287-297
Oligonucleotide-Based Therapeutics of Human Malignancies....Pages 298-326
Back Matter....Pages 327-331

✦ Subjects

Cell Biology; Biochemistry, general

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