Nucleic Acids and Molecular Biology

✍ Scribed by Th. D. Tullius (auth.), Professor Dr. Fritz Eckstein, Dr. David M. J. Lilley (eds.)

• Publisher: Springer-Verlag Berlin Heidelberg
• Year: 1989
• Tongue: English
• Leaves: 280
• Series: Nucleic Acids and Molecular Biology 3
• Edition: 1
• Category: Library

✦ Synopsis

A wide range of topics are covered, including articles on nucleic acid structure, through their interactions with proteins to the control of gene expression. A number of authors address the subject of RNA, including the difficult but important subject of its chemical synthesis, the complexities of its structures and the mechanisms of transcript splicing. The probing of DNA structure is reviewed in papers on the application of hydroxyl radical and 1,10 phenanthroline copper cleavages. A number of important DNA-protein interactions are discussed, including DNA polymerase, the tryptophan and deoR repressors, and the resolvase enzymes which cleave Holliday junctions in recombination. Gene transcription is also covered, from the points of view of DNA methylation, mammalian ribosomal and avian lysozyme genes, and the control of transcription in the proto-oncogene c-fos. Finally, the plant kingdom has not been forgotten with articles on development and transposition in plants.

✦ Table of Contents

Front Matter....Pages I-XI
Structural Studies of DNA Through Cleavage by the Hydroxyl Radical....Pages 1-12
DNase Activity of 1,10-Phenanthroline-Copper Ion....Pages 13-27
Structure of E. Coli DNA Polymerase I, Large Fragment, and Its Functional Implications....Pages 28-43
Resolution of Model Holliday Junctions in Vitro....Pages 44-55
Structure and Mechanism of the trp Repressor/Operator System....Pages 56-78
The deoR Repressor from E. coli and Its Action in Regulation-at-a-Distance....Pages 79-91
Complexities in Gene Regulation by Promoter Methylation....Pages 92-119
Transcriptional Regulation of Proto-Oncogene c-fos....Pages 120-132
The Structural and Functional Domain Organization of the Chicken Lysozyme Gene Locus....Pages 133-147
Mammalian Ribosomal Gene Transcription....Pages 148-163
The Chemical Synthesis of Oligo- and Poly-ribonucleotides....Pages 164-181
RNA Structure....Pages 182-196
Pre-mRNA Splicing in Yeast....Pages 197-215
Trans-Splicing of RNA....Pages 216-230
Structure and Function of Bacterial RNase P....Pages 231-250
Transposition in Plants....Pages 251-259
Transgenic Plants and the Study of Plant Development....Pages 260-268
Back Matter....Pages 269-272

✦ Subjects

Biochemistry, general; Cell Biology