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Nucleic acid probe containing fluorescent tricyclic base-linked acyclonucleoside for detection of single nucleotide polymorphisms

✍ Scribed by Kinji Furukawa; Mayumi Hattori; Tokimitsu Ohki; Yoshiaki Kitamura; Yukio Kitade; Yoshihito Ueno

Book ID
113495612
Publisher
Elsevier Science
Year
2012
Tongue
English
Weight
895 KB
Volume
20
Category
Article
ISSN
0968-0896

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Cover Picture: Forced Intercalation Prob
Cover Picture: Forced Intercalation Probes (FIT Probes): Thiazole Orange as a Fluorescent Base in Peptide Nucleic Acids for Homogeneous Single-Nucleotide-Polymorphism Detection (ChemBioChem 1/2005)
✍ Olaf KΓΆhler; Dilip Venkatrao Jarikote; Oliver Seitz πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 34 KB πŸ‘ 1 views

**The cover picture shows** new PNA probes–FIT Probes–and their use in homogenous DNA detection and was designed by Elke Socher. In FIT Probes, the thiazole orange dye is forced to intercalate at a specific position of a probe–target complex. In their paper on p. 69 ff, O. Seitz et al. describe how