Forced Intercalation Probes (FIT Probes): Thiazole Orange as a Fluorescent Base in Peptide Nucleic Acids for Homogeneous Single-Nucleotide-Polymorphism Detection

Cover Picture: Forced Intercalation Prob

Cover Picture: Forced Intercalation Probes (FIT Probes): Thiazole Orange as a Fluorescent Base in Peptide Nucleic Acids for Homogeneous Single-Nucleotide-Polymorphism Detection (ChemBioChem 1/2005)

✍ Olaf Köhler; Dilip Venkatrao Jarikote; Oliver Seitz 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 34 KB 👁 1 views

**The cover picture shows** new PNA probes–FIT Probes–and their use in homogenous DNA detection and was designed by Elke Socher. In FIT Probes, the thiazole orange dye is forced to intercalate at a specific position of a probe–target complex. In their paper on p. 69 ff, O. Seitz et al. describe how