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Nuclear uptake of NGF, EGF, PDGF and insulin, binding to chromatin receptors in tumour cell lines

✍ Scribed by Rakowicz-Szulczyńska, Ewa M.; Koprowski, Hilary


Book ID
122619401
Publisher
Elsevier Science
Year
1987
Weight
126 KB
Volume
23
Category
Article
ISSN
0277-5379

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✍ Ewa M. Rakowicz-Szulczynska; Danuta Otwiaska; Hilary Koprowski 📂 Article 📅 1990 🏛 John Wiley and Sons 🌐 English ⚖ 676 KB

## Abstract Analysis of different cellular fractions after incubation of SW 948 and SW 707 colorectal carcinoma cells or WM 266‐4 melanoma cells with ^125^I‐insulin revealed the nondegraded hormone in the chromatin of these cells. Nuclear ^125^1‐insulin was bound to specific fragments of EcoRI‐, Ha