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Nuclear Receptors as Drug Targets in Cholestatic Liver Diseases

โœ Scribed by Halilbasic, Emina; Baghdasaryan, Anna; Trauner, Michael


Book ID
120080696
Publisher
Elsevier Science
Year
2013
Tongue
English
Weight
404 KB
Volume
17
Category
Article
ISSN
1089-3261

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โœ Michael Trauner ๐Ÿ“‚ Article ๐Ÿ“… 2004 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 216 KB ๐Ÿ‘ 2 views

Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo