Farnesoid X receptor (FXR) is a bile acid-activated transcription factor that is a member of the nuclear hormone receptor superfamily. FXR-null mice exhibit a phenotype similar to Byler disease, an inherited cholestatic liver disorder. In the liver, activation of FXR induces transcription of transpo
โฆ LIBER โฆ
Nuclear receptors as therapeutic targets in cholestatic liver diseases
โ Scribed by Gernot Zollner; Michael Trauner
- Book ID
- 111218073
- Publisher
- Nature Publishing Group
- Year
- 2009
- Tongue
- English
- Weight
- 373 KB
- Volume
- 156
- Category
- Article
- ISSN
- 0007-1188
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Nuclear receptors are ligand-activated transcriptional regulators of several key aspects of hepatic physiology and pathophysiology. As such, nuclear receptors control a large variety of metabolic processes including hepatic lipid metabolism, drug disposition, bile acid homeostasis, as well as liver