Nuclear Receptors as Drug Targets

✍ Scribed by Eckhard Ottow (Editor), Hilmar Weinmann (Editor), Raimund Mannhold (Series Editor), Hugo Kubinyi (Series Editor), Gerd Folkers (Series Editor)

Publisher: Wiley-VCH
Year: 2008
Tongue: English
Leaves: 523
Series: Methods and Principles in Medicinal Chemistry (Book 39)
Edition: 1
Category: Library

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✦ Synopsis

G protein-coupled receptors (GPCRs) are one of the most important target classes in pharmacology and are the target of many blockbuster drugs. Yet only with the recent elucidation of the rhodopsin structure have these receptors become amenable to a rational drug design.

Based on recent examples from academia and the pharmaceutical industry, this book demonstrates how to apply the whole range of bioinformatics, chemoinformatics and molecular modeling tools to the rational design of novel drugs targeting GPCRs.

Essential reading for medicinal chemists and drug designers working with this largest class of drug targets in the human genome.

✦ Subjects

Медицинские дисциплины;Фармацевтика;Медицинская химия и разработка лекарств;

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