𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Nuclear receptors and regulation of bile acid synthesis in humans

Book ID
117638549
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
132 KB
Volume
14
Category
Article
ISSN
0939-4753

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Abbreviations ## CDCA chenodeoxycholic acid Cyp7A cholesterol 7Ξ±-hydroxylase DCA deoxycholic acid FRET fluorescence resonance energy transfer FXR farnesoid X receptor LCA lithocholic acid LRH-1 liver receptor homologue-1 LXR liver X receptor RXR retinoid X receptor SF-1 steroidogenic factor-1

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## Abstract Chemical genomics is the name we have given to the analysis of gene function through use of small molecule chemical tools. Orphan nuclear receptors are ideally suited to this technique of functional analysis, since their activity as transcription factors is regulated by small hydrophobi