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Nuclear Particles of Non-A, Non-B Type in Healthy Volunteers and Patients with Hepatitis B

✍ Scribed by Hanspeter Spichtin; Fred Gudat; Hans Berthold; Gunthild Krey; Martin Schmid; Mauro Pirovino; Josef Altorfer; Georg Stalder; Gerald Eder; Leonardo Bianchi

Publisher
John Wiley and Sons
Year
1984
Tongue
English
Weight
524 KB
Volume
4
Category
Article
ISSN
0270-9139

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✦ Synopsis

In an electron microscopic study, nuclear aggregates of virus-like spherical and tubular particles measuring 20 to 29 nm in diameter were found in 5 of 7 clinically healthy volunteers with normal liver histology, 6 of 10 patients with hepatitis B and 17 of 18 patients with hepatitis non-A, non-B. The incidence of hepatocytes containing nuclear particles was approximately 0.5 to 2% in all three groups. We conclude that these nuclear particles are not specific ultrastructural markers of hepatitis non-A, non-B in man as originally claimed for experimental hepatitis non-A, non-B in chimpanzees.

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