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Nuclear matrix as an anchor for protein kinase CK2 nuclear signalling

✍ Scribed by Sherif Tawfic; Russell A. Faust; Markus Gapany; Khalil Ahmed

Publisher: John Wiley and Sons
Year: 1996
Tongue: English
Weight: 676 KB
Volume: 62
Category: Article
ISSN: 0730-2312
DOI: 10.1002/(sici)1097-4644(199608)62:2<165::aid-jcb4>3.0.co;2-q

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✦ Synopsis

Nuclear matrix (NM) is not only the structural basis for nuclear shape but also is intimately involved in nuclear functional activities. Among the modulatory factors that may affect these diverse activities are the signals that may influence the state or composition of the NM proteins. One such mechanism for altering the functional activityof at least some NM proteins may be the extent of their phosphorylation. Protein kinase CK2 appears to associate with NM and to phosphorylate a number of NM-associated proteins. Chromatin-and NM-associated CK2 is rapidly modulated by mitogenic signals. We propose that NM serves as a physiological anchor for nuclear signalling of protein kinase CK2 which may influence functions of N M such as transcription of active genes and growth. o 1996 WiIey-Liss, Inc.

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