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Nuclear Localization Signal Peptides Enhance Cationic Liposome-Mediated Gene Therapy

✍ Scribed by Aronsohn, A. I.; Hughes, J. A.

Book ID: 118037901
Publisher: Informa plc
Year: 1998
Tongue: English
Weight: 803 KB
Volume: 5
Category: Article
ISSN: 1061-186X
DOI: 10.3109/10611869808995871

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## Abstract ## Background One of the major limitations of nonviral gene delivery methods is nuclear transport of plasmid DNA (pDNA). Peptides bearing nuclear localization signal (NLS) were shown to mediate nuclear import of macromolecules. We have explored the use of cell‐permeable peptides (CPP)