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Nuclear factor-κB regulates RANTES chemokine expression in response to tumor necrosis factor-α in fibroblast-like synoviocytes

✍ Scribed by F. Hirano; A. Kobayashi; Y. Hirano; Y. Nomura; E. Fukawa; I. Makino

Publisher: Springer
Year: 2002
Tongue: English
Weight: 230 KB
Volume: 12
Category: Article
ISSN: 1439-7595
DOI: 10.1007/s101650200006

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## Abstract ## Objective To investigate the roles of MAPKs and NF‐κB in tumor necrosis factor α (TNFα)–induced expression of vascular cell adhesion molecule 1 (VCAM‐1) in human rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods Human RASFs were isolated from synovial tissue obtained f