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The inhibition in tumor necrosis factor-α-induced attenuation in endothelial thrombomodulin expression by carvedilol is mediated by nuclear factor-κB and reactive oxygen species

✍ Scribed by Pen-Yuan Lin; Hsi-Che Shen; Chien-Jen Chen; Shu-En Wu; Hsien-Li Kao; Jen-Hung Huang; Danny Ling Wang; Shih-Chung Chen

Publisher: Springer US
Year: 2009
Tongue: English
Weight: 323 KB
Volume: 29
Category: Article
ISSN: 0929-5305
DOI: 10.1007/s11239-009-0318-2

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## Abstract ## Objective To examine the role of interferon regulatory factor 1 (IRF‐1) in tumor necrosis factor α (TNFα)–induced interleukin‐18 binding protein a (IL‐18BPa) expression in rheumatoid arthritis synovial fibroblasts (RASFs). ## Methods TNFα‐induced IRF‐1 expression was assessed by r