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Nuclear association of a T-cell transcription factor blocked by FK-506 and cyclosporin A

✍ Scribed by Flanagan, W. Michael; Corthésy, Blaise; Bram, Richard J.; Crabtree, Gerald R.

Book ID
109778042
Publisher
Nature Publishing Group
Year
1991
Tongue
English
Weight
849 KB
Volume
352
Category
Article
ISSN
0028-0836

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## Abstract The effects of the immunosuppressants cyclosporin A (CsA), FK506 and rapamycin have been compared using murine B cells activated with a variety of mitogens. FK506 is a macrolide antibiotic that has been recently shown to inhibit T cell activation by a mechanism that appears similar to t