Differentia] transcriptional regulation of endothelin-1 by immunosuppressants FK506 and cyclosporin A
โ Scribed by Tobias A. Marsen; Frank Weber; Guido Egink; Gudrun Suckau; Conrad A. Baldamus
- Book ID
- 111193952
- Publisher
- John Wiley and Sons
- Year
- 2000
- Tongue
- English
- Weight
- 734 KB
- Volume
- 14
- Category
- Article
- ISSN
- 0767-3981
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Cyclosporin A and FK-506 are important therapeutic agents that have found widespread use in preventing graft rejection during tissue transplantation. Research efforts aimed at elucidating the molecular mechanism of action of these drugs have, in addition to defining their immunosuppressive functions
Using two representative immunosuppressants, FK506 (FK) and cyclosporin A (CyA), of which the mechanism of pharmacological action is the same although there is a great difference in the pharmacological intensity, the distribution characteristics were studied in both in vivo and in vitro experiments