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Nuclear alterations in mammalian cells induced by L-canavanine

✍ Scribed by J. D. Hare

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
343 KB
Volume
75
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Mammalian cells treated four hours with the L‐arginine analogue, L‐canavanine (Cana), develop alterations in nuclear architecture characterized by the formation of irregular aggregates of nucleoplasmic contents, frequently attached to the nuclear membrane. On the basis of previous studies showing that Cana is incorporated into nuclear proteins and inhibits DNA synthesis over similar periods of exposure, it is postulated that the formation of canavanyl protein‐DNA aggregates interfere with DNA replication.

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