Nuchal thickness, urine β-core fragment level, and maternal age for Down syndrome screening
✍ Scribed by R.O. Bahado-Singh; A.U. Oz; D. Flores; D. Cermik; E. Acuna; M.J. Mahoney; L. Cole
- Book ID
- 113986190
- Publisher
- Elsevier Science
- Year
- 1999
- Tongue
- English
- Weight
- 111 KB
- Volume
- 180
- Category
- Article
- ISSN
- 1097-6868
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Several studies have shown that second-trimester maternal urine -core human chorionic gonadotrophin (hCG) levels are raised on average in Down syndrome pregnancies. However, in all but one, testing was retrospective after extended sample storage and so we carried out a large international multicentr
Two recent publications by Cuckle et al., and one each by Canick et al. and Kellner et al., describe the use of urine beta-core fragment measurements as a screening test for Down syndrome pregnancies. Median levels of over 5.4 MOM were reported for cases of Down syndrome, with an over 72 per cent de
Variable results have been reported using urine -core fragment as a marker for fetal Down syndrome. Initial studies by Cuckle et al. (1994) and Canick et al. (1995) indicated that -core fragment was an outstanding marker, detecting >80 per cent of Down syndrome cases. Since these reports, widely var