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NS-49, a novel α1a-adrenoceptor-selective agonist characterization using recombinant human α1-adrenoceptors

✍ Scribed by Kenji Obika; Katsushi Shibata; Kuniko Horie; Rudolf Foglar; Kiyoshi Kimura; Gozoh Tsujimoto

Book ID
113398899
Publisher
Elsevier Science
Year
1995
Tongue
English
Weight
792 KB
Volume
291
Category
Article
ISSN
0922-4106

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Renal excretion mechanism of NS-49, a ph
Renal excretion mechanism of NS-49, a phenethylamine class α1A-adrenoceptor agonist
✍ Hideya Mukai; Akira Morino 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

Renal handling of NS-49, which is an organic cation and a chiral compound, was investigated in rats, rabbits and dogs. Renal clearance (Cl re ) of NS-49 was 3.4-fold the glomerular filtration rate (GFR) in the rat in vivo study. The clearance ratio (Cl re /GFR) approached unity during cimetidine inf