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α1-Adrenoceptor subtypes and effect of α1A-adrenoceptor agonist NS-49 on guinea pig nasal mucosa vasculature

✍ Scribed by Noriaki Tanimitsu; Koji Yajin; Masashi Sasa; Hiromichi Tsuru


Book ID
114017705
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
207 KB
Volume
387
Category
Article
ISSN
0014-2999

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Renal excretion mechanism of NS-49, a ph
✍ Hideya Mukai; Akira Morino 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

Renal handling of NS-49, which is an organic cation and a chiral compound, was investigated in rats, rabbits and dogs. Renal clearance (Cl re ) of NS-49 was 3.4-fold the glomerular filtration rate (GFR) in the rat in vivo study. The clearance ratio (Cl re /GFR) approached unity during cimetidine inf