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NR4A2 genetic variation in sporadic Parkinson's disease: A genewide approach

✍ Scribed by Daniel G. Healy; Patrick M. Abou-Sleiman; Kourosh R. Ahmadi; Sonia Gandhi; Miratul M. Muqit; Kailash P. Bhatia; Niall P. Quinn; Andrew J. Lees; Janice L. Holton; Tamas Revesz; Nicholas W. Wood

Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
64 KB
Volume
21
Category
Article
ISSN
0885-3185

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✦ Synopsis

Abstract

The NR4A2 gene, which may cause autosomal dominant Parkinson's disease (PD), has also been reported to be a susceptibility factor for sporadic PD. Here, we use a haplotype‐tagging approach in 802 PD patients and 784 controls and demonstrate that common genetic variation, including NR4A2 haplotypes, does not influence the risk of PD in the Caucasian population. Β© 2006 Movement Disorder Society

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