Induction of hepatic stellate cell (HSC) apoptosis attenuates hepatic fibrosis, and, therefore, mechanisms to induce HSC cell death are of therapeutic interest. Proteasome inhibitors induce apoptosis in transformed cells, especially those cells dependent upon nuclear factor kappa B (NF-kappaB) activ
β¦ LIBER β¦
Noxa mediates hepatic stellate cell apoptosis by proteasome inhibition
β Scribed by Ivette M. Sosa Seda; Justin L. Mott; Yuko Akazawa; Fernando J. Barreyro; Steven F. Bronk; Scott H. Kaufmann; Gregory J. Gores
- Book ID
- 118088289
- Publisher
- John Wiley and Sons
- Year
- 2010
- Tongue
- English
- Weight
- 454 KB
- Volume
- 40
- Category
- Article
- ISSN
- 1386-6346
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