✦ LIBER ✦

Novel σ Receptor Ligands. Part 2. SAR of Spiro[[2]benzopyran-1,4‘-piperidines] and Spiro[[2]benzofuran-1,4‘-piperidines] with Carbon Substituents in Position 3

✍ Scribed by Maier, Christoph A.; Wünsch, Bernhard

Book ID: 121864754
Publisher: American Chemical Society
Year: 2002
Tongue: English
Weight: 143 KB
Volume: 45
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm020889p

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Pharmacological and metabolic characteri

Pharmacological and metabolic characterisation of the potent σ1 receptor ligand 1′-benzyl-3-methoxy-3H-spiro[[2]benzofuran-1,4′-piperidine]

✍ Christian Wiese; Eva Große Maestrup; Dirk Schepmann; Jose Miguel Vela; Jörg Hole 📂 Article 📅 2009 🏛 Pharmaceutical Press 🌐 English ⚖ 296 KB

Synthesis and derivatisation of a novel

Synthesis and derivatisation of a novel spiro[1-benzofuran-2,4′-piperidin]-3-one scaffold

✍ Wilson, Rowan A.; Chan, Lai; Wood, Robin; Brown, Richard C. D. 📂 Article 📅 2005 🏛 Royal Society of Chemistry 🌐 English ⚖ 252 KB

Thiophene Bioisosteres of Spirocyclic σ

Thiophene Bioisosteres of Spirocyclic σ Receptor Ligands. 1. N-Substituted Spiro[piperidine-4,4′-thieno[3,2- c ]pyrans]

✍ Oberdorf, Christoph; Schepmann, Dirk; Vela, Jose Miguel; Diaz, Jose Luis; Holenz 📂 Article 📅 2008 🏛 American Chemical Society 🌐 English ⚖ 309 KB

Enantioselective σ1 receptor binding and

Enantioselective σ1 receptor binding and biotransformation of the spirocyclic PET tracer 1′-benzyl-3-(3-fluoropropyl)-3H-spiro[[2]benzofuran-1,4′-piperidine]

✍ Christian Wiese; Eva Große Maestrup; Dirk Schepmann; Stefan Grimme; Hans-Ulrich 📂 Article 📅 2010 🏛 John Wiley and Sons 🌐 English ⚖ 300 KB

Novel radical synthesis of morphine frag

Novel radical synthesis of morphine fragments spiro[benzofuran-3(2H),4′-piperidine] and octahydro-1H-benzofuro[3,2-e]isoquinoline

✍ Chen-Yu Cheng; Ling-Wei Hsin; Jing-Ping Liou 📂 Article 📅 1996 🏛 Elsevier Science 🌐 French ⚖ 569 KB

ChemInform Abstract: Spiro-Substituted P

ChemInform Abstract: Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (.+-.)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1′-yl)butyl]-N-methylbenzamides and Evaluation of NK1—NK2 Dual Antagonistic Activities.

✍ Hirokazu Kubota; ET AL. ET AL. 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 36 KB 👁 2 views

Spiro-Substituted Piperidines as Neurokinin Receptor Antagonists. Part 3. Synthesis of (±)-N-[2-(3,4-Dichlorophenyl)-4-(spiro-substituted piperidin-1'-yl)butyl]-N-methylbenzamides and Evaluation of NK 1 -NK 2 Dual Antagonistic Activities. -In order to obtain more potent NK 1 -NK 2 dual antagonists a