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Novel unusual microbial dehalogenation during enantioselective reduction of ethyl 4,4,4-trifluoro acetoacetate with baker's yeast

✍ Scribed by Martin Bertau


Book ID
104211734
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
59 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis


In the course of investigating microbial syntheses for chiral pharmaceutical intermediates, ethyl 4,4,4-trifluoro acetoacetate (1) was submitted to baker's yeast reduction. With the purpose of obtaining the D-carbinol in high enantiopurity, several additives were tested for L-reductase inhibitor activity. Allyl alcohol proved to be not only a suitable additive, but also an inducer for effective defluorination of the substrate.


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