## Abstract **BACKGROUND:** The enantioselectivity of reduction of ethyl 2‐oxo‐4‐phenylbutyrate (EOPB) to synthesize ethyl (__R__)‐2‐hydroxy‐4‐phenylbutyrate ((__R__)‐EHPB) catalyzed with baker's yeast in diethyl ether can be improved by the introduction of alpha‐phenacyl chloride (PC). However, th
✦ LIBER ✦
Novel unusual microbial dehalogenation during enantioselective reduction of ethyl 4,4,4-trifluoro acetoacetate with baker's yeast
✍ Scribed by Martin Bertau
- Book ID
- 104211734
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 59 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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✦ Synopsis
In the course of investigating microbial syntheses for chiral pharmaceutical intermediates, ethyl 4,4,4-trifluoro acetoacetate (1) was submitted to baker's yeast reduction. With the purpose of obtaining the D-carbinol in high enantiopurity, several additives were tested for L-reductase inhibitor activity. Allyl alcohol proved to be not only a suitable additive, but also an inducer for effective defluorination of the substrate.
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