Novel serotonin type 3 receptor partial
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David D. Manning; Christopher L. Cioffi; Alexander Usyatinsky; Kevin Fitzpatrick
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Article
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2011
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Elsevier Science
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English
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Serotonin type 3 (5-HT(3)) receptor partial agonists are being targeted as potential new drugs for the treatment of irritable bowel syndrome (IBS). Two new chemical series bearing indazole and indole cores have exhibited nanomolar binding affinity for the h5-HT(3)A receptor. A range of partial agoni