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Novel treatments for irritable bowel syndrome


Book ID
120862626
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2002
Weight
139 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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Serotonin type 3 (5-HT(3)) receptor partial agonists are being targeted as potential new drugs for the treatment of irritable bowel syndrome (IBS). Two new chemical series bearing indazole and indole cores have exhibited nanomolar binding affinity for the h5-HT(3)A receptor. A range of partial agoni