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Novel transformation of 23-bromosapogenins. Synthesis of (22S,23R)-22-hydroxy-23,26-epoxyfurostanes

✍ Scribed by Jacek W Morzycki; Izabella Jastrzębska

Book ID
104231223
Publisher
Elsevier Science
Year
2001
Tongue
French
Weight
146 KB
Volume
42
Category
Article
ISSN
0040-4039

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✦ Synopsis

22S,23S

)-23-Bromosapogenins undergo rearrangement to the (22S,23R)-22-hydroxy-23,26-epoxyfurostanes during alkaline hydrolysis. An efficient degradation procedure of sarsapogenin via the corresponding bisfuran to the C 22 lactone is described.

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Stereoselective synthesis of (22R, 23R,
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✍ Braja G. Hazra; Padmakar L. Joshi; Bharat B. Bahule; Narshinha P. Argade; Vandan 📂 Article 📅 1994 🏛 Elsevier Science 🌐 French ⚖ 760 KB

## Abstnzck: A new synthesis of the important aldehyde I torn easily available l&Dehydropregnenolone acetate (I6-DPA) in high yield is described. The aidehyde I ip converted to trio1 24, involving a stereaselective generation of all the four chiral centers in the brassinolide side chain. The importa