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Novel thioxo-.beta.-lactams from thiosulfinates derived from penicillin sulfoxides

โœ Scribed by Chou, T. S.; Koppel, G. A.; Dorman, D. E.; Paschal, J. W.


Book ID
126282308
Publisher
American Chemical Society
Year
1976
Tongue
English
Weight
269 KB
Volume
98
Category
Article
ISSN
0002-7863

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Penicillin imino chlorides III. A novel
โœ R.D Carroll; Larry L. Reed ๐Ÿ“‚ Article ๐Ÿ“… 1975 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 245 KB

In a previous communication' we described base-catalyzed rearrangement of the imino chloride 1 of penicillin V methyl ester to oxazole 9. In the work described herein we report formation of novel B-lactam 8 which arises, after a complicated series of steps, from the interaction of 1 with ketene 3.