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Novel targets in HPV-negative head and neck cancer: overcoming resistance to EGFR inhibition

✍ Scribed by Burtness, Barbara; Bauman, Julie E; Galloway, Thomas


Book ID
121448317
Publisher
The Lancet
Year
2013
Tongue
English
Weight
964 KB
Volume
14
Category
Article
ISSN
1470-2045

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Mechanisms of resistance to EGFR inhibit
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## Abstract Epidermal growth factor receptor (EGFR), a receptor tyrosine kinase that activates multiple signaling pathways, including phosphatidylinositol‐3‐kinase/v‐AKT murine thymoma viral oncogene homolog protein (Akt), has long been a target of novel therapies. Despite universal EGFR expression