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Novel Synthetic Methodologies. Part 99. Facile One-Pot Multicomponent Synthesis of β-Acetamido Ketones with Amberlyst-15 as Heterogeneous Catalyst.

✍ Scribed by Biswanath Das; Kongara Ravinder Reddy


Publisher
John Wiley and Sons
Year
2007
Weight
29 KB
Volume
38
Category
Article
ISSN
0931-7597

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Facile One-Pot Multicomponent Synthesis
✍ Biswanath Das; Kongara Ravinder Reddy 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 German ⚖ 49 KB

## Abstract The one‐pot multicomponent coupling of an aromatic aldehyde, an enolizable ketone or keto ester, acetonitrile, and acetyl chloride at room temperature in the presence of __Amberlyst‐15__ as catalyst affords __β__‐acetamido ketones in high yields. The inexpensive catalyst works under het