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Facile One-Pot Multicomponent Synthesis of β-Acetamido Ketones with Amberlyst-15 as Heterogeneous Catalyst

✍ Scribed by Biswanath Das; Kongara Ravinder Reddy


Publisher
John Wiley and Sons
Year
2006
Tongue
German
Weight
49 KB
Volume
89
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The one‐pot multicomponent coupling of an aromatic aldehyde, an enolizable ketone or keto ester, acetonitrile, and acetyl chloride at room temperature in the presence of Amberlyst‐15 as catalyst affords β‐acetamido ketones in high yields. The inexpensive catalyst works under heterogeneous conditions and can be readily reused.


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