Facile One-Pot Multicomponent Synthesis of β-Acetamido Ketones with Amberlyst-15 as Heterogeneous Catalyst
✍ Scribed by Biswanath Das; Kongara Ravinder Reddy
- Publisher
- John Wiley and Sons
- Year
- 2006
- Tongue
- German
- Weight
- 49 KB
- Volume
- 89
- Category
- Article
- ISSN
- 0018-019X
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✦ Synopsis
Abstract
The one‐pot multicomponent coupling of an aromatic aldehyde, an enolizable ketone or keto ester, acetonitrile, and acetyl chloride at room temperature in the presence of Amberlyst‐15 as catalyst affords β‐acetamido ketones in high yields. The inexpensive catalyst works under heterogeneous conditions and can be readily reused.
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