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Novel synthetic derivatives of the natural product berbamine inhibit Jak2/Stat3 signaling and induce apoptosis of human melanoma cells

✍ Scribed by Nam, Sangkil; Xie, Jun; Perkins, Angela; Ma, Yuelong; Yang, Fan; Wu, Jun; Wang, Yan; Xu, Rong-zhen; Huang, Wendong; Horne, David A.; Jove, Richard

Book ID: 119328979
Publisher: Wiley (John Wiley & Sons)
Year: 2012
Tongue: English
Weight: 865 KB
Volume: 6
Category: Article
ISSN: 1574-7891
DOI: 10.1016/j.molonc.2012.05.002

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## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator