Inhibition of the JAK-2/STAT3 signaling pathway impedes the migratory and invasive potential of human glioblastoma cells
✍ Scribed by Christian Senft; Maike Priester; Margareth Polacin; Katrin Schröder; Volker Seifert; Donat Kögel; Jakob Weissenberger
- Publisher
- Springer US
- Year
- 2010
- Tongue
- English
- Weight
- 491 KB
- Volume
- 101
- Category
- Article
- ISSN
- 0167-594X
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
## Abstract Aberrant janus kinase/signal transducers and activators of transcription (JAK/STAT) signaling is involved in the oncogenesis of several cancers. Suppressors of cytokine signaling (SOCS) genes and SH2‐containing protein tyrosine phosphatase 1 (SHP1) proteins, which are negative regulator
## Abstract In __de novo__ glioblastoma multiforme, loss of the tumour suppressor protein PTEN can coincide with the expression of a naturally occurring mutant epidermal growth factor receptor known as ΔEGFR. ΔEGFR signals constitutively via the phosphatidylinositol 3‐kinase (PI3K)/protein kinase A