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Novel Sesquiterpenes from Ligularia virgaurea spp. oligocephala

✍ Scribed by Xia Liu; Quan-Xiang Wu; Xiao-Ning Wei; Yan-Ping Shi

Publisher
John Wiley and Sons
Year
2007
Tongue
German
Weight
106 KB
Volume
90
Category
Article
ISSN
0018-019X

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✦ Synopsis

Abstract

Two novel sesquiterpene dimers, ligularin A (1) and ligulolide D (2), and one new sesquiterpenoid, 1__β__,10__α__‐dihydroxy‐6__β__‐[(2‐methylpropyl)oxy]furanoeremophil‐9‐one (3), as well as two known sesquiterpenoids, 6__β__‐[(2‐methylpropyl)oxy]‐furanoeremophil‐1(10)‐en‐9‐one (4) and 1‐hydroxy‐3,7‐dimethyl‐2‐(pent‐3‐enyl)benzofuran (5), were isolated from the petroleum‐ether fraction from an alcoholic extract of the whole plant of Ligularia virgaurea spp. oligocephala. Their structures were elucidated by 1D and 2D‐NMR spectroscopy together with HR‐ESI‐MS analysis, and comparison of the spectroscopic data with those reported for structurally related compounds. In addition, the cytotoxicities against human gastric cancer SGC‐7910 cell were measured in vitro, the results demonstrated that these sesquiterpenes have no cytotoxicity against the selected tumor cell (all IC~50~ values >200 μM).

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## Abstract From the BuOH extract of the whole plant of __Ligularia virgaurea__ spp. __oligocephala__, a series of sesquiterpenes, sesquiterpene glycosides, and lignan glycosides were isolated, including the three new compounds (1__α__)‐1‐hydroxy‐8‐oxo‐eremophila‐6,9‐dien‐12‐oic acid (**1**), 8‐[(_