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Novel selective hypotensive vasopressin peptides: cardiovascular and structure–activity-relationship studies

✍ Scribed by W.Y Chan; Roberto Levi; Nga Ching Wo; Motohiro Koyama; Stoytcho Stoev; Ling Ling Cheng; Maurice Manning

Book ID
114013899
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
97 KB
Volume
419
Category
Article
ISSN
0014-2999

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Synthesis and structure–activity investi
Synthesis and structure–activity investigation of novel vasopressin hypotensive peptide agonists
✍ Maurice Manning; Stoytcho Stoev; Ling Ling Cheng; Nga Ching Wo; W.Y. Chan 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 175 KB 👁 1 views

We report the solid phase synthesis and vasodepressor potencies of the novel hypotensive peptide [1(-i-mercapto-i,i-pentamethylene propionic acid)-2-O-ethyl-D-tyrosine, 3-arginine, 4-valine] arginine vasopressin, d(CH 2 ) 5 [D-Tyr(Et) 2 , Arg 3 , Val 4 ]AVP (A), its related Lys 3 (B), Tyr-NH 2 9 (C)