Novel reactions of carbon suboxide. Synthesis of 1,5-benzodioxepins, 1,5-benzoxathiepins and 1,5-benzoxazepins
✍ Scribed by Leonardo Bonsignore; Giuseppe Loy; Mario Secci; Salvatore Cabiddu
- Book ID
- 112126886
- Publisher
- Journal of Heterocyclic Chemistry
- Year
- 1982
- Tongue
- English
- Weight
- 121 KB
- Volume
- 19
- Category
- Article
- ISSN
- 0022-152X
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## Abstract Novel polysubstituted ‐1,5‐benzothiazepine, ‐1,5‐benzoxazepine, and ‐1,5‐benzodiazepine were prepared in good yields by the reaction of hydrazono derivatives with __o__‐thioaminophenol, __o__‐aminophenol and __o__‐phenylenediamine __via__ a one‐pot reaction.
## Abstract A simple approach to the fluorinated 1,5‐benzoxazepine ring system is described. By reacting commercially accessible aminophenols 1 and the trifluoroacetylvinyl ether 2, high yields of enaminones 3 were obtained. Functionalization of methyl group of compounds 3 gave rise to dieneamines