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Novel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces

โœ Scribed by Dong, Ke; Tang, Lie-Qi; MacGregor, Gordon G; Leng, Qiang; Hebert, Steven C


Book ID
110031021
Publisher
Nature Publishing Group
Year
2005
Tongue
English
Weight
444 KB
Volume
24
Category
Article
ISSN
0261-4189

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ATP-inhibited potassium channels (K(ATP)) were studied in excised, inside-out patches from cultured adult mouse pancreatic beta-cells and HIT cells. In the absence of ATP, ADP opened K(ATP) channels at concentrations as low as 10 microM and as high as 500 microM, with maximal activation between 10 a